The traditional method of housing mice and rats alone increases stress and worsens epilepsy, according to a new study published in eNeuro. The added stress could complicate results of pre-clinical drug trials.
Rodents are typically housed alone to prevent aggressive behaviors and simplify data collection. However, rats and mice are social animals, and isolation causes stress that could be a confounding factor in studies.
eNeuro Editor-in-Chief Christophe Bernard and colleagues examined how epileptic and healthy mice and rats fared in social or isolated housing conditions. They found that the isolated, healthy rodents displayed higher levels of stress and anxiety compared to the healthy rodents living in groups. Epileptic rodents also had more severe seizures when they were isolated, likely due to the increased stress of their environment.
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