(HealthDay)—Low-density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) ≥160 mg/dL are independently associated with increased relative risk of cardiovascular disease (CVD) mortality in a low-risk cohort, according to a study published online Aug. 20 in Circulation.
Shuaib M. Abdullah, M.D., from the VA North Texas Medical Center in Dallas, and colleagues examined the long-term associations of various LDL-C and non-HDL-C thresholds and mortality in a cohort of 36,375 participants defined as low-risk for 10-year atherosclerotic CVD events (median age, 42).
The researchers identified 1,086 CVD and 598 coronary heart disease deaths during a median follow-up of 26.8 years. LDL-C categories of 100 to 129, 130 to 159, 160 to 189.9, and ≥190 mg/dL correlated with a significantly elevated risk of CVD death compared with LDL-C <100 mg/dL (hazard ratios, 1.4, 1.3, 1.9, and 1.7, respectively), and with mean reductions of 1.8, 1.1, 4.3, and 3.9 years free of CVD death, respectively. LDL-C categories of 160 to 189 and ≥190 mg/dL remained independently associated with CVD mortality after adjustment for atherosclerotic CVD risk factors (hazard ratios, 1.7 and 1.5, respectively). Using non-HDL-C <130 mg/dL as the reference, non-HDL-C 160 to 189, 190 to 219, and ≥220 mg/dL were significantly associated with CVD death, in multivariable-adjusted models, with hazard ratios of 1.3, 1.8, and 1.5, respectively.
“These findings may have implications for future cholesterol treatment paradigms,” the authors write.
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